Synthesis of novel azole-fused quinazolines via one-pot, sequential Ullmann-type coupling and intramolecular dehydrogenative C-N bonding

被引：33
作者：
Nandwana, Nitesh Kumar [1 ]
Pericherla, Kasiviswanadharaju [1 ]
Kaswan, Pinku [1 ]
Kumar, Anil [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 10期
关键词：
H FUNCTIONALIZATION; DIRECT ARYLATION; COPPER; AMINATION; AGENTS;
D O I：
10.1039/c4ob02375g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot sequential procedure is described for the synthesis of novel azole-fused quinazolines through Pd/Cu co-catalyzed, Ullmann-type coupling followed by cross dehydrogenative coupling of various azoles such as 1H-imidazole, 1H-benzimidazole and 1H-1,2,4-triazole with 2-(2-bromophenyl)1H-imidazole/benzimidazoles. The developed strategy has offered good yields (52-81%) of diverse N-fused tetra-, penta- and hexa-cyclic frameworks in a single step.
引用
收藏
页码：2947 / 2950
页数：4
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