PCSK9-A Journey to Cardiovascular Outcomes

被引：16

作者：

Burnett, John R. ^{[1
]}

Hooper, Amanda J.

机构：

[1] Univ Western Australia, Sch Med, Perth, WA, Australia

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 22期

关键词：

REDUCING LIPIDS; ALIROCUMAB; EVOLOCUMAB; EFFICACY; SAFETY;

D O I：

10.1056/NEJMe1813758

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2161 / 2162

页数：2

共 10 条

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].

Abifadel, M ;

Varret, M ;

Rabès, JP ;

Allard, D ;

Ouguerram, K ;

Devillers, M ;

Cruaud, C ;

Benjannet, S ;

Wickham, L ;

Erlich, D ;

Derré, A ;

Villéger, L ;

Farnier, M ;

Beucler, I ;

Bruckert, E ;

Chambaz, J ;

Chanu, B ;

Lecerf, JM ;

Luc, G ;

Moulin, P ;

Weissenbach, J ;

Prat, A ;

Krempf, M ;

Junien, C ;

Seidah, NG ;

Boileau, C .

NATURE GENETICS, 2003, 34 (02) :154-156

[2] 'Highest risk-highest benefit' strategy: a pragmatic, cost-effective approach to targeting use of PCSK9 inhibitor therapies [J].

Annemans, Lieven ;

Packard, Chris J. ;

Briggs, Andrew ;

Ray, Kausik K. .

EUROPEAN HEART JOURNAL, 2018, 39 (27) :2546-2550

[3] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

[4] Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans [J].

Reyes-Soffer, Gissette ;

Pavlyha, Marianna ;

Ngai, Colleen ;

Thomas, Tiffany ;

Holleran, Stephen ;

Ramakrishnan, Rajasekhar ;

Karmally, Wahida ;

Nandakumar, Renu ;

Fontanez, Nelson ;

Obunike, Joseph ;

Marcovina, Santica M. ;

Lichtenstein, Alice H. ;

Matthan, Nirupa R. ;

Matta, James ;

Maroccia, Magali ;

Becue, Frederic ;

Poitiers, Franck ;

Swanson, Brian ;

Cowan, Lisa ;

Sasiela, William J. ;

Surks, Howard K. ;

Ginsberg, Henry N. .

CIRCULATION, 2017, 135 (04) :352-+

[5] Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events [J].

Robinson, Jennifer G. ;

Farnier, Michel ;

Krempf, Michel ;

Bergeron, Jean ;

Luc, Gerald ;

Averna, Maurizio ;

Stroes, Erik S. ;

Langslet, Gisle ;

Raal, Frederick J. ;

El Shahawy, Mahfouz ;

Koren, Michael J. ;

Lepor, Norman E. ;

Lorenzato, Christelle ;

Pordy, Robert ;

Chaudhari, Umesh ;

Kastelein, John J. P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (16) :1489-1499

[6]

Sabatine MS, 2017, NEW ENGL J MED, V376, P1713, DOI [10.1056/NEJMoa1615664, 10.4997/JRCPE.2017.212]

[7] Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events [J].

Sabatine, Marc S. ;

Giugliano, Robert P. ;

Wiviott, Stephen D. ;

Raal, Frederick J. ;

Blom, Dirk J. ;

Robinson, Jennifer ;

Ballantyne, Christie M. ;

Somaratne, Ransi ;

Legg, Jason ;

Wasserman, Scott M. ;

Scott, Robert ;

Koren, Michael J. ;

Stein, Evan A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (16) :1500-1509

[8] Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome [J].

Schwartz, G. G. ;

Steg, P. G. ;

Szarek, M. ;

Bhatt, D. L. ;

Bittner, V. A. ;

Diaz, R. ;

Edelberg, J. M. ;

Goodman, S. G. ;

Hanotin, C. ;

Harrington, R. A. ;

Jukema, J. W. ;

Lecorps, G. ;

Mahaffey, K. W. ;

Moryusef, A. ;

Pordy, R. ;

Quintero, K. ;

Roe, M. T. ;

Sasiela, W. J. ;

Tamby, J. -F. ;

Tricoci, P. ;

White, H. D. ;

Zeiher, A. M. ;

Aylward, Philip E. ;

Drexel, Heinz ;

Sinnaeve, Peter ;

Dilic, Mirza ;

Lopes, Renato D. ;

Gotcheva, Nina N. ;

Goodman, Shaun G. ;

Prieto, Juan-Carlos ;

Yong, Huo ;

Lopez-Jaramillo, Patricio ;

Pecin, Ivan ;

Reiner, Zeljko ;

Ostadal, Petr ;

Poulsen, Steen Hvitfeldt ;

Viigimaa, Margus ;

Nieminen, Markku S. ;

Danchin, Nicolas ;

Chumburidze, Vakhtang ;

Marx, Nikolaus ;

Liberopoulos, Evangelos ;

Montenegro Valdovinos, Pablo Carlos ;

Tse, Hung-Fat ;

Kiss, Robert Gabor ;

Xavier, Denis ;

Zahger, Doron ;

Valgimigli, Marco ;

Kimura, Takeshi ;

Kim, Hyo Soo .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (22) :2097-2107

[9] PCSK9 From Basic Science Discoveries to Clinical Trials [J].

Shapiro, Michael D. ;

Tavori, Hagai ;

Fazio, Sergio .

CIRCULATION RESEARCH, 2018, 122 (10) :1420-1438

[10] Factorial Effects of Evolocumab and Atorvastatin on Lipoprotein Metabolism [J].

Watts, Gerald F. ;

Chan, Dick C. ;

Dent, Ricardo ;

Somaratne, Ransi ;

Wasserman, Scott M. ;

Scott, Rob ;

Burrows, Sally ;

Barrett, P. Hugh R. .

CIRCULATION, 2017, 135 (04) :338-+

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