Building Models of Brain Disorders with Three-Dimensional Organoids

被引：229

作者：

Amin, Neal D. ^{[1
]}

Pasca, Sergiu P. ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

来源：

NEURON | 2018年 / 100卷 / 02期

关键词：

PLURIPOTENT STEM-CELLS; ZIKA VIRUS-INFECTION; CEREBRAL ORGANOIDS; NEURAL PROGENITORS; FUNCTIONAL MATURATION; ENVIRONMENTAL-FACTORS; CORTICAL DEVELOPMENT; NEURONAL MIGRATION; SELF-ORGANIZATION; BIPOLAR DISORDER;

D O I：

10.1016/j.neuron.2018.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features of the human brain with greater complexity than 2D models and are increasingly being applied to model diseases affecting the central nervous system. Here, we review the use of human brain organoids to investigate neurological and psychiatric (neuropsychiatric) disorders and how this technology may ultimately advance our biological understanding of these conditions.

引用

页码：389 / 405

页数：17

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