Synthesis and Structural and Biochemical Activity Studies of Dioxime Ligand and its Mononuclear Cu(II), Ni(II), and Co(II) Complexes

A new tetradentate ligand incorporating dioxime moities has been synthesized. Its copper(II), nickel(II), and cobalt(II) complexes have been prepared and characterized by spectral methods. Elemental analyses and spectroscopic data of the metal complexes are consistent with the formation of the mononuclear copper(II), nickel(II) and cobalt(II) complexes. The crystal structure of the (2E, 2'E)-butane-2,3-dione 2,2'-{O-2,O-2'-[1,2-phenylenebis(methylene)]oxime compound (3) was determined by single-crystal x-ray diffraction technique. The free ligand and copper(II), nickel(II), and cobalt(II) complexes (5-7) were tested against the morphology of series bacteria. The Cu(II), Ni(II), and Co(II) complexes exhibit higher activity than dioxime ligand under identical experimental conditions.