A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]

被引：228

作者：

Litvinas, Nichole D. ^{[1
,2
]}

Fier, Patrick S. ^{[1
,2
]}

Hartwig, John F. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 02期

关键词：

copper; fluorine; one-pot methodology; perfluoroalkylation; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; ARYL IODIDES; FUNCTIONALIZATION;

D O I：

10.1002/anie.201106668

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile method for the synthesis of aryl perfluoroalkanes from arenes and aryl bromides is described. Substituted arenes or aryl bromides are converted in situ to an aryl boronate ester that readily undergoes perfluoroalkylation in air with [(phen)CuR F]. A broad range of aryl bromide substrates were perfluoroalkylated in good yield for the first time. [(phen)CuCF 3] is now commercially available and has been prepared on 20g scale. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：536 / 539

页数：4

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