Control of organ-specific autoimmunity by immunoregulatory CD4+CD25+ T cells

被引：47

作者：

McHugh, RS ^{[1
]}

Shevach, EM ^{[1
]}

Thornton, AM ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 11期

关键词：

autoimmunity; suppressor T cells; autoimmune gastritis;

D O I：

10.1016/S1286-4579(01)01453-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：919 / 927

页数：9

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[1] An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation [J].