Inverse agonist binding of peripheral benzodiazepine receptors in anxiety disorder

被引:4
作者
Chiu, S [1 ]
Singh, AN [1 ]
Chiu, P [1 ]
Mishra, RK [1 ]
机构
[1] McMaster Univ, Dept Psychiat Behav Neurosci, Neuropharmacol Lab, Hamilton, ON L8N 3Z5, Canada
基金
英国医学研究理事会;
关键词
anxiety; inverse agonist; peripheral benzodiazepine receptors;
D O I
10.1007/s004060170048
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The binding characteristics of the pBR (peripheral benzodiazepine receptor) inverse agonist, [H-3]-Ro, 5-4864, were examined in patients diagnosed as generalized anxiety disorder. As compared to normal healthy controls, the anxious subjects demonstrated a statistically significant (p < 0.001) increase in the density of pBR in platelets. The enhanced pBR binding correlated significantly with the severity of global anxiety symptom of the Hamilton Anxiety Rating Scale (HAR-S, p < 0.001). The Psychic component, but not the Somatic component, of the HAR-S, correlated significantly (p < 0.001) with the enhanced pBR binding in platelets. The results provide evidence for the hypothesis of dysregulation of peripheral benzodiazepine receptors in generalized anxiety disorder.
引用
收藏
页码:136 / 140
页数:5
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