Tacrolimus-related polyneuropathy: Case report and review of the literature

被引：23

作者：

De Weerdt, Annick ^{[1
]}

Claeys, Kristl G. ^{[2
]}

De Jonghe, Peter ^{[2
]}

Ysebaert, Dirk ^{[3
]}

Chapelle, Thiery ^{[3
]}

Roeyen, Geert ^{[3
]}

Jorens, Philippe G. ^{[1
]}

机构：

[1] Univ Antwerp, Univ Antwerp Hosp, Dept Crit Care Med, B-2650 Edegem, Belgium

[2] Univ Antwerp, Univ Antwerp Hosp, Dept Neurol, Antwerp, Belgium

[3] Univ Antwerp Hosp, Dept Hepatobiliary Transplantat & Endocrine Surg, Antwerp, Belgium

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2008年 / 110卷 / 03期

关键词：

tacrolimus; liver transplantation; neurotoxicity; polyneuropathy; immunoglobulins;

D O I：

10.1016/j.clineuro.2007.10.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all I I reported FK506-associated polyneuropathies is given. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：291 / 294

页数：4

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