Sedative effect of walnut leaf extract and juglone, an isolated constituent

被引：50

作者：

Gîrzu, M

Carnat, A

Privat, AM

Fialip, J

Carnat, AP

Lamaison, JL

机构：

[1] Fac Pharm Clermont Ferrand, Lab Pharmacognosie & Phytotherapie, F-63100 Clermont Ferrand, France

[2] Fac Pharm Clermont Ferrand, Pharmacol Lab, F-63001 Clermont Ferrand, France

来源：

PHARMACEUTICAL BIOLOGY | 1998年 / 36卷 / 04期

关键词：

Juglans regia L; chloroform extract; juglone; sedative activity; mice motivity; sleep potentiation;

D O I：

10.1076/phbi.36.4.280.4580

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sedative activity of Juglans regia L. (Juglandaceae) chloroform extract and of one of its isolated constituents was evaluated in mice. Dry chloroform extract and juglone, orally administered at 6.5 mg/kg and 0.125 mg/kg, respectively, induced marked sedation as measured by two tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). A separation method of juglone from chloroform extract was developed.

引用

页码：280 / 286

页数：7

共 16 条

[1]

BEZANGERBEAUQUE.L, 1990, PLANTES MED REGIONS, P58

[2] ANTITUMOR ACTIVITY OF JUGLANS NIGRA [BLACK WALNUT) EXTRACTIVES [J].

BHARGAVA, UC ;

WESTFALL, BA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (10) :1674-&

[3]

BOISSIER J.-R, 1960, MED EXPTL, V3, P81

[4]

BOISSIER JR, 1965, ARCH INT PHARMACOD T, V158, P212

[5]

BOISSIER JR, 1960, THERAPIE, V15, P1170

[6]

Bruneton J., 1999, PHARMACOGOSIE PHYTOC, P418

[7] A NOTE ON A SIMPLE APPARATUS FOR DETECTING NEUROLOGICAL DEFICIT IN RATS AND MICE [J].

DUNHAM, NW ;

MIYA, TS .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1957, 46 (03) :208-209

[8]

FOURNIER P, 1948, LIVRE PLANTES MED VE, V3, P104

[9]

HUSSON GP, 1986, ANN PHARM FR, V44, P41

[10]

LECLERC M, 1976, PRECIS PHYTOTHERAPIE, P105

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