Synthesis of 2′-C-methyl-branched isonucleosides

被引：11

作者：

Bouisset, Tony ^{[1
]}

Gosselin, Gilles ^{[1
]}

Griffe, Ludovic ^{[1
]}

Meillon, Jean-Christophe ^{[1
]}

Storer, Richard ^{[1
]}

机构：

[1] Lab Chim Med Idenix, F-34189 Montpellier 4, France

来源：

TETRAHEDRON | 2008年 / 64卷 / 28期

关键词：

nucleoside analogues; isonucleosides; Valopicitabine; hepatitis C; anti-virals;

D O I：

10.1016/j.tet.2008.05.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel regioisomers of 2'-methyl-branched nucleosides were designed and synthesized to mimic potent anti-viral drugs like Valopicitabine. The short and efficient synthesis of the targets involves a one-pot tosylation/cyclization step that leads to an activated furan scaffold on which the isonucleosides were built. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：6657 / 6661

页数：5

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