An expeditious synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines

被引：13

作者：

Khan, MW ^{[1
]}

Kundu, NG ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Organ Chem, Calcutta 700032, W Bengal, India

来源：

JOURNAL OF CHEMICAL RESEARCH | 1999年 / 01期

关键词：

D O I：

10.1039/a806787b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines is described where the Friedel-Crafts reaction on 2,6-dichloropyrimidine-4-carbonyl chloride plays a crucial role.

引用

页码：20 / +

页数：4

共 27 条

[1] 3,4-DIHYDRO-2-ALKOXY-6-BENZYL-4-OXOPYRIMIDINES (DABOS) - A NEW CLASS OF SPECIFIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

ARTICO, M ;

MASSA, S ;

MAI, A ;

MARONGIU, ME ;

PIRAS, G ;

TRAMONTANO, E ;

LACOLLA, P .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1993, 4 (06) :361-368

[2] HIGHLY SPECIFIC-INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 BY A NOVEL 6-SUBSTITUTED ACYCLOURIDINE DERIVATIVE [J].

BABA, M ;

TANAKA, H ;

DECLERCQ, E ;

PAUWELS, R ;

BALZARINI, J ;

SCHOLS, D ;

NAKASHIMA, H ;

PERNO, CF ;

WALKER, RT ;

MIYASAKA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1375-1381

[3]

Brown D. J., 1985, PYRIMIDINES

[4] Palladium-catalysed synthesis of some biologically active 5,6-disubstituted uracils [J].

Das, P ;

Spears, CP ;

Shahinian, AH ;

Dasgupta, SK ;

Kundu, NG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (20) :2477-2480

[5] In search of a selective antiviral chemotherapy [J].

DeClercq, E .

CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (04) :674-+

[6]

DECLERCQ E, 1979, P NATL ACAD SCI USA, V76, P2947, DOI 10.1073/pnas.76.6.2947

[7] CHEMOTHERAPEUTIC APPROACHES TO THE TREATMENT OF THE ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME (AIDS) [J].

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1561-1569

[8]

Gallo R. C., 1986, Scientific American, V255

[9]

256, P78

[10]

GALLO RC, 1988, SCI AM, V256, P45

← 1 2 3 →