A New Stilbenoid from Caryopteris incana

被引：1

作者：

Chen, Dekun ^{[1
,2
]}

Zhang, Kai ^{[3
]}

Tan, Jianbing ^{[2
]}

Zhang, Sha ^{[2
]}

Xu, Kangping ^{[2
]}

Wang, Wenxuan ^{[2
]}

Kang, Fenghua ^{[2
]}

Zou, Zhenxing ^{[1
,2
]}

Tan, Guishan ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Changsha 410008, Peoples R China

[2] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China

[3] Fuyang Peoples Hosp, Dept Pharm, Fuyang 236000, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 02期

基金：

湖南省自然科学基金; 中国国家自然科学基金;

关键词：

Verbenaceae; Caryopteris incana; chemical constituents; stilbenoid; cytotoxity; CONSTITUENTS; GLYCOSIDES;

D O I：

10.1007/s10600-022-03640-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new stilbenoid, methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (1), along with 11 known compounds, cirsimaritin (2), cirsiliol (3), quercetin (4), apigenin (5), acacetin (6), genkwanin (7), luteolin (8), caffeic acid (9), esculetin (10), alternariol (11), and alternariol-5-O-methyl ether (12), was isolated from the 70% EtOH extract of Caryopteris incana. The structures of these compounds were established via extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS. Compound 1 exhibited moderate cytotoxic activity against human HepG2 and SMMC-7721 hepatoma cell lines with IC50 values of 21.3 and 20.1 mu M, respectively.

引用

页码：199 / 202

页数：4

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