Simple hemoglobin-gold nanoparticles modified electrode for the amperometric detection of acrylamide

被引：56

作者：

Garabagiu, Sorina ^{[1
]}

Mihailescu, Gheorghe ^{[1
]}

机构：

[1] Natl Inst R&D Isotop & Mol Technol, Cluj Napoca 400293, Romania

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2011年 / 659卷 / 02期

关键词：

ITO glass; Gold nanoparticles; Hemoglobin adduct; Acrylamide; SURFACE-PLASMON SPECTROSCOPY; HYDROGEN-PEROXIDE BIOSENSOR; DIRECT ELECTROCHEMISTRY; VOLTAMMETRIC BIOSENSOR; FOOD; IMMOBILIZATION; ATTACHMENT; MYOGLOBIN; GROWTH; FILMS;

D O I：

10.1016/j.jelechem.2011.06.003

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work we propose the design of an electrochemical setup (hemoglobin-gold-nanoparticles-ITO glass), used for the determination of a hemoglobin adduct (acrylamide). Acrylamide is neurotoxin and potential carcinogen, formed mainly in high temperatures processed food that contains large quantity of starch (French fries, baked bread). Acrylamide forms hemoglobin adducts, and our sensing device is based on this property, by passivating the hemoglobin-modified electrode by the addition of low concentrations of acrylamide. The sensitivity to acrylamide better as 0.1 mu M makes this electrochemical cell configuration suitable for the detection of acrylamide in food products. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：196 / 200

页数：5

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