TLR-based immune adjuvants

被引：400

作者：

Steinhagen, Folkert ^{[1
]}

Kinjo, Takeshi ^{[1
]}

Bode, Christian ^{[1
]}

Klinman, Dennis M. ^{[1
]}

机构：

[1] NCI, Canc & Inflammat Program, Frederick, MD 21702 USA

来源：

VACCINE | 2011年 / 29卷 / 17期

关键词：

Toll-like receptor ligand; Vaccination; Adjuvant; HEPATITIS-B-VACCINE; T-CELL RESPONSES; POLYRIBOINOSINIC-POLYRIBOCYTIDYLIC ACID; HUMAN-PAPILLOMAVIRUS TYPE-16; TUMOR-NECROSIS-FACTOR; DOUBLE-STRANDED-RNA; MONOPHOSPHORYL-LIPID-A; TOLL-LIKE RECEPTORS; PHASE-II TRIAL; IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGONUCLEOTIDE;

D O I：

10.1016/j.vaccine.2010.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results are available. Published by Elsevier Ltd.

引用

页码：3341 / 3355

页数：15

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