Tumor delivery of macromolecular drugs based on the EPR effect

被引：1609

作者：

Torchilin, Vladimir ^{[1
]}

机构：

[1] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2011年 / 63卷 / 03期

关键词：

Tumors; Drug delivery; EPR effect; Protein drugs; Peptide drugs; Polymeric drugs; Pharmaceutical nanocarriers; Tumor targeting; Intracellular drug delivery; PEGYLATED-LIPOSOMAL DOXORUBICIN; LONG-CIRCULATING LIPOSOMES; PHASE-II TRIAL; IN-VIVO; ENHANCED PERMEABILITY; TARGETED DELIVERY; VASCULAR-PERMEABILITY; POLYMERIC MICELLES; SOLID TUMORS; CANCER;

D O I：

10.1016/j.addr.2010.03.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：131 / 135

页数：5

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