Blosignaling of mammalian Ste20-related kinases

被引：116

作者：

Ling, Pin ^{[2
]}

Lu, Te-Jung ^{[3
]}

Yuan, Chiun-Jye ^{[4
]}

Lai, Ming-Derg ^{[1
,5
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan

[3] Chung Hwa Univ Med Technol, Coll Med & Life Sci, Dept Med Technol, Tainan, Taiwan

[4] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan

[5] Natl Cheng Kung Univ, Ctr Gene Regulat & Signal Transduct Res, Tainan 70101, Taiwan

来源：

CELLULAR SIGNALLING | 2008年 / 20卷 / 07期

关键词：

ste20; kinase; signal pathway; MST; apoptosis contents;

D O I：

10.1016/j.cellsig.2007.12.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1237 / 1247

页数：11

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