Synthesis, characterization and thermal studies of binary and/or mixed ligand complexes of Cd(II), Cu(II), Ni(II) and Co(III) based on 2-(Hydroxybenzylidene) thiosemicarbazone: DNA binding affinity of binary Cu(II) complex

被引:61
作者
Saif, M. [1 ]
Mashaly, Mahmoud M. [1 ]
Eid, Mohamed F. [1 ]
Fouad, R. [1 ]
机构
[1] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt
关键词
2-(Hydroxybenzylidene) thiosemicarbazone; Binary and ternary complexes; Thermal studies; DNA binding; TRANSITION-METAL-COMPLEXES; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; MACROCYCLIC COMPLEXES; TEMPLATE SYNTHESIS; ZN(II) COMPLEXES; SCHIFF-BASES; SEMICARBAZONE; COBALT(III); DERIVATIVES;
D O I
10.1016/j.saa.2012.02.098
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
A new series of metal complexes of Cd(II), Cu(II), Ni(II) and Co(III) with Schiff base ligand, H2L, 2-(Hydroxybenzylidene) thiosemicarbazone were synthesized. The mixed ligand complexes were prepared by using glycine (Gly), 2-aminopyridine (2-Ampy) and 1,10-phenanthroline (Phen) as secondary ligands. The structure of these complexes was identified and confirmed by elemental analysis, molar conductivity, UV-Vis, FT-IR and H-1 NMR spectroscopy and magnetic moment measurements as well as TG-DSC technique. The discussions of the prepared complexes indicate that the ligand behaves as a monoanionic tridentate ligand through ONS donor sites. Thermal studies suggested a mechanism for the degradation of the metal complexes as a function of temperature supporting the chelation modes and showed the possibility of obtaining new complexes pyrolytically in the solid state which cannot be synthesized from the solution. The absorption studies support that the binary Cu(II) complex exhibits a significant binding affinity to HS-DNA through intercalative mode. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:347 / 356
页数:10
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