Involvement of forebrain imidazoline and α2-adrenergic receptors in the antidipsogenic response to moxonidine

被引：7

作者：

Andrade, CAF ^{[1
]}

Oliveira, LB ^{[1
]}

Martinez, G ^{[1
]}

Silva, DCF ^{[1
]}

De Luca, LA ^{[1
]}

Menani, JV ^{[1
]}

机构：

[1] UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil

来源：

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES | 2003年 / 1009卷

关键词：

thirst; angiotensin II; dehydration; water intake;

D O I：

10.1196/annals.1304.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the participation of central alpha(2)-adrenoceptors and imidazoline receptors in the inhibition of water deprivation-induced water intake in rats. The alpha(2)-adrenoceptor and imidazoline antagonist idazoxan (320 nmol), but not the alpha(2)-adrenoceptor antagonist yohimbine, abolished the antidipsogenic effect of moxonidine (alpha(2)-adrenoceptor and imidazoline agonist, 20 nmol) microinjected into the medial septal area. Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly. Therefore, central moxonidine may inhibit water intake acting independently on both imidazoline receptors and alpha(2)-adrenoceptors at different forebrain sites.

引用

页码：262 / 264

页数：3

共 3 条

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De Luca, LA .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2001, 34 (09) :1185-1190

[3] Receptor-mediated effects of clonidine on need-induced 3% NaCl and water intake [J].

Yada, MM ;

dePaula, PM ;

Menani, JV ;

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BRAIN RESEARCH BULLETIN, 1997, 42 (03) :205-209

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