Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey

被引:16
作者
Blumental, Sophie [1 ]
Huisman, Elisabeth [2 ]
Cornet, Marie-Coralie [3 ]
Ferreiro, Christine [4 ]
De Schutter, Iris [2 ]
Reynders, Marijke [5 ]
Wybo, Ingrid [6 ]
Kabamba-Mukadi, Benoit [7 ]
Armano, Ruth [3 ]
Hermans, Dominique [3 ]
Nassogne, Marie-Cecile [3 ]
Mahadeb, Bhavna [8 ]
Fonteyne, Christine [9 ]
Van Berlaer, Gerlant [10 ]
Levy, Jack [4 ]
Moulin, Didier [3 ]
Vergison, Anne [1 ,11 ]
Malfroot, Anne [2 ]
Lepage, Philippe [1 ]
机构
[1] Hop Univ Enfants Reine Fabiola HUDERF, Pediat Infect Dis Unit, Brussels, Belgium
[2] Univ Ziekenhuis Brussel, Pediat Pneumol & Infect Dis Dept, Brussels, Belgium
[3] Clin Univ St Luc UCLouvain, Dept Pediat, Brussels, Belgium
[4] Hop Univ St Pierre, Dept Pediat, B-1000 Brussels, Belgium
[5] Hop Univ St Pierre, Microbiol Unit, B-1000 Brussels, Belgium
[6] UZB, Microbiol Unit, Brussels, Belgium
[7] UCLouvain, Microbiol Unit, Brussels, Belgium
[8] HUDERF, Dept Pediat, Brussels, Belgium
[9] HUDERF, Intens Care Unit, Brussels, Belgium
[10] UZB, Emergency & Intens Care Unit, Brussels, Belgium
[11] HUDERF, Infect Control Unit, Brussels, Belgium
关键词
A H1N1 VIRUS; UNITED-STATES; A(H1N1); INFECTION; PNEUMONIA; DEATHS; CARE;
D O I
10.1186/1471-2334-11-313
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: During the 2009 influenza A/H1N1v pandemic, children were identified as a specific "at risk" group. We conducted a multicentric study to describe pattern of influenza A/H1N1v infection among hospitalized children in Brussels, Belgium. Methods: From July 1, 2009, to January 31, 2010, we collected epidemiological and clinical data of all proven (positive H1N1v PCR) and probable (positive influenza A antigen or culture) pediatric cases of influenza A/H1N1v infections, hospitalized in four tertiary centers. Results: During the epidemic period, an excess of 18% of pediatric outpatients and emergency department visits was registered. 215 children were hospitalized with proven/probable influenza A/H1N1v infection. Median age was 31 months. 47% had >= 1 comorbid conditions. Febrile respiratory illness was the most common presentation. 36% presented with initial gastrointestinal symptoms and 10% with neurological manifestations. 34% had pneumonia. Only 24% of the patients received oseltamivir but 57% received antibiotics. 10% of children were admitted to PICU, seven of whom with ARDS. Case fatality-rate was 5/215 (2%), concerning only children suffering from chronic neurological disorders. Children over 2 years of age showed a higher propensity to be admitted to PICU (16% vs 1%, p = 0.002) and a higher mortality rate (4% vs 0%, p = 0.06). Infants less than 3 months old showed a milder course of infection, with few respiratory and neurological complications. Conclusion: Although influenza A/H1N1v infections were generally self-limited, pediatric burden of disease was significant. Compared to other countries experiencing different health care systems, our Belgian cohort was younger and received less frequently antiviral therapy; disease course and mortality were however similar.
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