Recent Progresses on AI-2 Bacterial Quorum Sensing Inhibitors

被引：31

作者：

Zhu, Peng ^{[1
]}

Li, Minyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Sch Pharm, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

AI-2; bacteria; inhibitors; LuxP; LuxS; quorum sensing; S-RIBOSYLHOMOCYSTEINASE LUXS; DIFFERENTIAL GENE-EXPRESSION; CELL-CELL COMMUNICATION; DNA-BINDING ACTIVITY; VIBRIO-HARVEYI; CATALYTIC MECHANISM; ESCHERICHIA-COLI; BORONIC ACIDS; AUTOINDUCER-2-LIKE ACTIVITY; STRUCTURAL IDENTIFICATION;

D O I：

10.2174/092986712803414187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quorum sensing (QS) is a communication procedure that predominates gene expression in response to cell density and fluctuations in the neighboring environment as a result of discerning molecules termed autoinducers (AIs). It has been embroiled that QS can govern bacterial behaviors such as the secretion of virulence factors, biofilm formation, bioluminescence production, conjugation, sporulation and swarming motility. Autoinducer 2 (AI-2), a QS signaling molecule brought up to be involved in interspecies communication, exists in both gram-negative and -positive bacteria. Therefore, novel approaches to interrupt AI-2 quorum sensing are being recognized as next generation antimicrobials. In the present review article, we summarized recent progresses on AI-2 bacterial quorum sensing inhibitors and discussed their potential as the antibacterial agents.

引用

页码：174 / 186

页数：13

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