Many Tumors in One: A Daunting Therapeutic Prospect

被引：31
作者：
Ene, Chibawanye I. [1 ]
Fine, Howard A. [1 ]
机构：
[1] NCI, Neurooncol Branch, Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA
来源：
CANCER CELL | 2011年 / 20卷 / 06期
关键词：
STEM-CELLS; GLIOBLASTOMA; CANCER; EVOLUTION;
D O I：
10.1016/j.ccr.2011.11.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Snuderl and coworkers demonstrate intratumoral genetic heterogeneity in glioblastoma based on in situ amplification of distinct genomic loci within individual cells in a mutually exclusive pattern. These findings may herald trouble for current targeted therapies but provide insights for future treatment strategies.
引用
收藏
页码：695 / 697
页数：3
相关论文
共 10 条
  • [1] Bailey P, 1926, CLASSIFICATION TUMOR, P1
  • [2] Tumour evolution inferred by single-cell sequencing
    Navin, Nicholas
    Kendall, Jude
    Troge, Jennifer
    Andrews, Peter
    Rodgers, Linda
    McIndoo, Jeanne
    Cook, Kerry
    Stepansky, Asya
    Levy, Dan
    Esposito, Diane
    Muthuswamy, Lakshmi
    Krasnitz, Alex
    McCombie, W. Richard
    Hicks, James
    Wigler, Michael
    [J]. NATURE, 2011, 472 (7341) : 90 - U119
  • [3] Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
    Ricci-Vitiani, Lucia
    Pallini, Roberto
    Biffoni, Mauro
    Todaro, Matilde
    Invernici, Gloria
    Cenci, Tonia
    Maira, Giulio
    Parati, Eugenio Agostino
    Stassi, Giorgio
    Larocca, Luigi Maria
    De Maria, Ruggero
    [J]. NATURE, 2010, 468 (7325) : 824 - U121
  • [4] Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
    Snuderl, Matija
    Fazlollahi, Ladan
    Le, Long P.
    Nitta, Mai
    Zhelyazkova, Boryana H.
    Davidson, Christian J.
    Akhavanfard, Sara
    Cahil, Daniel P.
    Aldape, Kenneth D.
    Betensky, Rebecca A.
    Louis, David N.
    Iafrate, A. John
    [J]. CANCER CELL, 2011, 20 (06) : 810 - 817
  • [5] Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
    Stephens, Philip J.
    Greenman, Chris D.
    Fu, Beiyuan
    Yang, Fengtang
    Bignell, Graham R.
    Mudie, Laura J.
    Pleasance, Erin D.
    Lau, King Wai
    Beare, David
    Stebbings, Lucy A.
    McLaren, Stuart
    Lin, Meng-Lay
    McBride, David J.
    Varela, Ignacio
    Nik-Zainal, Serena
    Leroy, Catherine
    Jia, Mingming
    Menzies, Andrew
    Butler, Adam P.
    Teague, Jon W.
    Quail, Michael A.
    Burton, John
    Swerdlow, Harold
    Carter, Nigel P.
    Morsberger, Laura A.
    Iacobuzio-Donahue, Christine
    Follows, George A.
    Green, Anthony R.
    Flanagan, Adrienne M.
    Stratton, Michael R.
    Futreal, P. Andrew
    Campbell, Peter J.
    [J]. CELL, 2011, 144 (01) : 27 - 40
  • [6] Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Stupp, R
    Mason, WP
    van den Bent, MJ
    Weller, M
    Fisher, B
    Taphoorn, MJB
    Belanger, K
    Brandes, AA
    Marosi, C
    Bogdahn, U
    Curschmann, J
    Janzer, RC
    Ludwin, SK
    Gorlia, T
    Allgeier, A
    Lacombe, D
    Cairncross, JG
    Eisenhauer, E
    Mirimanoff, RO
    Van Den Weyngaert, D
    Kaendler, S
    Krauseneck, P
    Vinolas, N
    Villa, S
    Wurm, RE
    Maillot, MHB
    Spagnolli, F
    Kantor, G
    Malhaire, JP
    Renard, L
    De Witte, O
    Scandolaro, L
    Vecht, CJ
    Maingon, P
    Lutterbach, J
    Kobierska, A
    Bolla, M
    Souchon, R
    Mitine, C
    Tzuk-Shina, T
    Kuten, A
    Haferkamp, G
    de Greve, J
    Priou, F
    Menten, J
    Rutten, I
    Clavere, P
    Malmstrom, A
    Jancar, B
    Newlands, E
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (10) : 987 - 996
  • [7] Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Verhaak, Roel G. W.
    Hoadley, Katherine A.
    Purdom, Elizabeth
    Wang, Victoria
    Qi, Yuan
    Wilkerson, Matthew D.
    Miller, C. Ryan
    Ding, Li
    Golub, Todd
    Mesirov, Jill P.
    Alexe, Gabriele
    Lawrence, Michael
    O'Kelly, Michael
    Tamayo, Pablo
    Weir, Barbara A.
    Gabriel, Stacey
    Winckler, Wendy
    Gupta, Supriya
    Jakkula, Lakshmi
    Feiler, Heidi S.
    Hodgson, J. Graeme
    James, C. David
    Sarkaria, Jann N.
    Brennan, Cameron
    Kahn, Ari
    Spellman, Paul T.
    Wilson, Richard K.
    Speed, Terence P.
    Gray, Joe W.
    Meyerson, Matthew
    Getz, Gad
    Perou, Charles M.
    Hayes, D. Neil
    [J]. CANCER CELL, 2010, 17 (01) : 98 - 110
  • [8] Notch Promotes Radioresistance of Glioma Stem Cells
    Wang, Jialiang
    Wakeman, Timothy P.
    Lathia, Justin D.
    Hjelmeland, Anita B.
    Wang, Xiao-Fan
    White, Rebekah R.
    Rich, Jeremy N.
    Sullenger, Bruce A.
    [J]. STEM CELLS, 2010, 28 (01) : 17 - 28
  • [9] Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    Wu, Adam
    Wei, Jun
    Kong, Ling-Yuan
    Wang, Yongtao
    Priebe, Waldemar
    Qiao, Wei
    Sawaya, Raymond
    Heimberger, Amy B.
    [J]. NEURO-ONCOLOGY, 2010, 12 (11) : 1113 - 1125
  • [10] Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    Yachida, Shinichi
    Jones, Sian
    Bozic, Ivana
    Antal, Tibor
    Leary, Rebecca
    Fu, Baojin
    Kamiyama, Mihoko
    Hruban, Ralph H.
    Eshleman, James R.
    Nowak, Martin A.
    Velculescu, Victor E.
    Kinzler, Kenneth W.
    Vogelstein, Bert
    Iacobuzio-Donahue, Christine A.
    [J]. NATURE, 2010, 467 (7319) : 1114 - U126
1