Many Tumors in One: A Daunting Therapeutic Prospect

被引：31

作者：

Ene, Chibawanye I. ^{[1
]}

Fine, Howard A. ^{[1
]}

机构：

[1] NCI, Neurooncol Branch, Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA

来源：

CANCER CELL | 2011年 / 20卷 / 06期

关键词：

STEM-CELLS; GLIOBLASTOMA; CANCER; EVOLUTION;

D O I：

10.1016/j.ccr.2011.11.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Snuderl and coworkers demonstrate intratumoral genetic heterogeneity in glioblastoma based on in situ amplification of distinct genomic loci within individual cells in a mutually exclusive pattern. These findings may herald trouble for current targeted therapies but provide insights for future treatment strategies.

引用

页码：695 / 697

页数：3

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