Blocking autophagy to prevent parasite differentiation

被引：36

作者：

Alvarez, Vanina E. ^{[2
]}

Kosec, Gregor ^{[1
]}

Sant'Anna, Celso ^{[3
]}

Turk, Vito

Cazzulo, Juan J. ^{[2
]}

Turk, Boris ^{[1
]}

机构：

[1] Jozef Stefan Inst, Dept Biochem Mol & Struct Biol, SI-1000 Ljubljana, Slovenia

[2] Consejo Nacl Invest Cient & Tecn, UNSAM, INTECH, IIB, RA-1033 Buenos Aires, DF, Argentina

[3] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagos Filho, Lab Ultraestrutura Celular Hertha Meyer, Rio De Janeiro, Brazil

来源：

AUTOPHAGY | 2008年 / 4卷 / 03期

关键词：

autophagy; Trypanosoma cruzi; differentiation; autophagin; ATG4; ATG8; infection; protease; Chagas disease;

D O I：

10.4161/auto.5592

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The genome of Trypanosoma cruzi was surveyed for autophagy-related genes. We have identified all the essential genes except for the Atg12 conjugation system and demonstrated functionality of the putative ATG4 and ATG8 homologs. TcAtg4.1 was primarily involved in the proteolytic processing of TcAtg8.1, the ATG8-homolog that was found to be localized to autophagosomal membranes during starvation. Autophagy was also found to be strongly upregulated during differentiation between developmental stages, a process that is essential for the propagation of the parasite. Based on our work, new strategies for treatment of Chagas disease, a chronic debilitating condition still without suitable chemotherapy, can be envisioned.

引用

页码：361 / 363

页数：3

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