Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

被引:14
作者
Song, Moon-Young [1 ]
Lee, Da-Young [1 ]
Park, Sang-Yong [2 ]
Seo, Seul-A [2 ]
Hwang, Jeong-Seung [2 ]
Heo, Soo-Hyeon [2 ]
Kim, Eun-Hee [1 ]
机构
[1] CHA Univ, Coll Pharm, Inst Pharmaceut Sci, Seongnam, South Korea
[2] SD Biotechnol Co Ltd, Seoul, South Korea
关键词
Steamed ginger extract; Helicobacter pylori; Gastritis; Anti-inflammation; NF-kappa B; NITRIC-OXIDE; TRANSCRIPTION; RESPONSES; HEALTH;
D O I
10.15430/JCP.2021.26.4.289
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ginger (Zingiber officinale) has traditionally been used as a treatment for inflammatory diseases in the Asian region. Recently, anti-inflammatory effects of steamed ginger extract (GGE03) have been reported, but its association with Helicobacter pylori (H. pylori)-induced gastritis has not been investigated. The purpose of this study was to assess the anti-inflammatory activity of GGE03 in H. pylon-infected gastric epithelial cells. Our studies revealed that the GGE03 suppressed the growth of H. pylori. GGE03 markedly reduced the expression of the H. pylori-induced pro-inflammatory cytokines including interleukin (IL)-8, TNF-alpha, IL-6, inducible NOS (iNOS) and IFN-gamma. We also demonstrated that GGE03 treatment inhibited the H. pylori-activated NF-kappa B signaling pathway. In addition, the treatment with GGE03 significantly attenuated nitric oxide production and myeloperoxidase activity in H. pylori-infected gastric epithelial cells. These anti-inflammatory effects of GGE03 were more effective than ginger extract. Finally, we investigated the minimum effective concentration of GGE03 to inhibit H. pylori-induced inflammation. Our findings suggest that GGE03 not only inhibits the growth of H. pylori, but also attenuates H. pylori-induced inflammation.
引用
收藏
页码:289 / 297
页数:9
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