Evaluation of novel MicroRNA profile-21 and 191 in oral leukoplakia and oral squamous cell carcinoma in comparison with healthy tissues - A cross-sectional study

被引：5
作者：
Muth Lakshmi, K. S. Sethana [1 ]
Lakshmi, Krithika Chandrasekar [1 ]
Kannan, A. [1 ]
Aniyan, Yesoda [1 ]
机构：
[1] SRM Dent Coll, Dept Oral Med & Radiol, Chennai 600089, Tamil Nadu, India
来源：
CLINICAL CANCER INVESTIGATION JOURNAL | 2021年 / 10卷 / 06期
关键词：
MicroRNA; molecular biology; oral leukoplakia; oral squamous cell carcinoma; premalignant; MIRNA EXPRESSION PROFILES; NATURAL-HISTORY; FOLLOW-UP; HEAD; LESIONS; TRANSFORMATION; DYSPLASIA; PROGNOSIS; SIGNATURE; CANCER;
D O I：
10.4103/ccij.ccij_54_21
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: The objective of this study was to identify whether microRNA (miR)-21 and miR-191 could be used as a potential biomarker in patients diagnosed with oral leukoplakia (OL) and oral squamous cell carcinoma. The aim of this study was to evaluate the expression of miR-21 and miR-191 in patients diagnosed with OL and oral squamous cell carcinoma. Materials and Methods: Fifteen patients each diagnosed with OL and oral squamous cell carcinoma and 15 healthy controls were recruited for the study. The miR was extracted from the tissue samples for the evaluation of miR-21 and miR-191 using RT-qPCR. Results: The miR-21 (P = 0.0005) and miR-191 (P = 0.0094) were significantly expressed in oral squamous cell carcinoma in comparison with healthy tissues. The expression of miR-191 was also significantly overexpressed (P = 0.0460) in OL in comparison with healthy tissues. Conclusion: The profile miR-21 and miR-191 could be used as a novel biomarker for oral squamous cell carcinoma and miR-191 could be used as a biomarker for OL.
引用
收藏
页码：275 / 282
页数：8
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