Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

被引：11

作者：

Druillennec, S ^{[1
]}

Meudal, H ^{[1
]}

Roques, BP ^{[1
]}

Fournié-Zaluski, MC ^{[1
]}

机构：

[1] UFR Sci Pharmaceut & Biol, Dept Pharmacochim Mol & Struct, CNRS, UMR 8600,INSERM,U266, F-75270 Paris 06, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

nucleomimetics; NCp7; HIV-1; inhibitors;

D O I：

10.1016/S0960-894X(99)00052-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis and biological properties of three modified dinucleotides T*G, G*T and T*T in winch the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：627 / 632

页数：6

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