Highly stereoselective aldol reactions of titanium enolates from ethyl alpha-silyloxyalkyl ketones

被引：29

作者：

Figueras, S ^{[1
]}

Martin, R ^{[1
]}

Romea, P ^{[1
]}

Urpi, F ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC QUIM,DEPT QUIM ORGAN,E-08028 BARCELONA,CATALONIA,SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)00108-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldol-like reactions of titanium enolates derived from alpha-OH, alpha-OBn, and alpha-OTBS ketones with a series of aldehydes have been studied. In sharp contrast to the O-benzyl derivatives, the TBS-protected ketones lead to excellent yields and selectivities (syn-syn/anti-syn ratios from 30:1 to > 95:1) even for the lactate-derived substrate (2-tert-butyldimethylsilyloxy-3-pentanone). (C) 1997 Elsevier Science Ltd.

引用

页码：1637 / 1640

页数：4

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