Protective effects of berberine on various kidney diseases: Emphasis on the promising effects and the underlined molecular mechanisms

被引：17

作者：

Hassanein, Emad H. M. ^{[1
]}

Ibrahim, Islam M. ^{[2
]}

Abd-Alhameed, Esraa K. ^{[3
]}

Mohamed, Nesma M. ^{[4
]}

Ross, Samir A. ^{[5
,6
]}

机构：

[1] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Assiut, Egypt

[2] Al Azhar Univ, Fac Pharm, Assiut, Egypt

[3] Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf, Egypt

[4] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt

[5] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA

[6] Univ Mississippi, Sch Pharm, Dept BioMol Sci, Div Pharmacognosy, University, MS 38677 USA

来源：

LIFE SCIENCES | 2022年 / 306卷

关键词：

Berberine; Renal diseases; Antioxidant; Anti-inflammatory; TUBULAR EPITHELIAL-CELLS; ACUTE-RENAL-FAILURE; HIGH-FAT DIET; NF-KAPPA-B; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; INDUCED APOPTOSIS; ISCHEMIA/REPERFUSION INJURY; SIGNALING PATHWAYS; MESANGIAL CELLS;

D O I：

10.1016/j.lfs.2022.120697

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Berberine (BBR) is a pentacyclic benzylisoquinoline alkaloid that can be found in diversity of medicinal plants. BBR has a wide range of pharmacological bioactivities, in addition when administrated orally, it has a broad safety margin. It has been used as an antidiarrheal, antimicrobial, and anti-diabetic drug in Ayurvedic and Chinese medicine. Several scholars have found that BBR has promising renoprotective effects against different renal illnesses, including diabetic nephropathy, renal fibrosis, renal ischemia, renal aging, and renal stones. Also, it has renopmtective effects against nephrotoxicity induced by chemotherapy, heavy metal, aminoglycosides, NSAID, and others. These effects imply that BBR has an evolving therapeutic potential against acute renal failure and chronic renal diseases. Hence, we report herein the beneficial therapeutic renopmtective properties of BBR, as well as the highlighted molecular mechanism. In conclusion, the studies discussed throughout this review will afford a comprehensive overview about renoprotective effect of BBR and its therapeutic impact on different renal diseases.

引用

页数：14

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