A time-dependent effect of caffeine upon lesion-induced plasticity

被引：5

作者：

Cabral-Miranda, F. ^{[1
]}

Serfaty, C. A. ^{[1
]}

Campello-Costa, P. ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Biol, Programa Neurociencias, Dept Neurobiol, BR-24001970 Niteroi, RJ, Brazil

来源：

NEUROSCIENCE RESEARCH | 2011年 / 71卷 / 01期

关键词：

Plasticity; Retinal lesion; Critical period; Caffeine; Adenosine receptors; RAT SUPERIOR COLLICULUS; LONG-TERM POTENTIATION; RETINOTECTAL PROJECTION; AFFERENTS; BLOCKADE; PATHWAY; ADULT;

D O I：

10.1016/j.neures.2011.05.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A(1) and A(2a) antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30 mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：99 / 102

页数：4

共 19 条

[1] Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina [J].