Understanding the role of the gut ecosystem in diabetes mellitus

被引:113
作者
Aw, Wanping [1 ]
Fukuda, Shinji [1 ,2 ]
机构
[1] Keio Univ, Inst Adv Biosci, Tsuruoka, Yamagata, Japan
[2] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan
关键词
Gut microbiota; Metabolomics; Metagenomics; INTESTINAL MICROBIOTA; BILE-ACIDS; UNITED-STATES; METABOLISM; BACTERIA; ONSET; RAT; TRANSLOCATION; ASSOCIATION; HOMEOSTASIS;
D O I
10.1111/jdi.12673
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes mellitus is a type of metabolic disorder whereby patients are unable to regulate glycemia. It is currently a worldwide public health issue, and is a burden to society because of its disabling and common complications. Diabetes is multifactorial, and also induces the onset of other diseases. In the present report, we review the labyrinth encompassing the gut microbiota and gut microbiota-derived metabolites in type 1 diabetes and type 2 diabetes pathogenesis. There have been exceptional improvements in deoxyribonucleic acid sequencing and mass spectrometry technologies throughout these past years, and these have allowed the comprehensive collection of information on our unique gut ecosystem. We would like to advocate incorporating metagenome and metabolome information for a comprehensive perspective of the complex interrelationships between the gut environment, host metabolism and diabetes pathogenesis. We hope that with this improved understanding we would be able to provide exciting novel therapeutic approaches to engineer an ideal gut ecosystem for optimal health.
引用
收藏
页码:5 / 12
页数:8
相关论文
共 76 条
[1]   Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment [J].
Amar, Jacques ;
Chabo, Chantal ;
Waget, Aurelie ;
Klopp, Pascale ;
Vachoux, Christelle ;
Bermudez-Humaran, Luis G. ;
Smirnova, Natalia ;
Berge, Mathieu ;
Sulpice, Thierry ;
Lahtinen, Sampo ;
Ouwehand, Arthur ;
Langella, Philippe ;
Rautonen, Nina ;
Sansonetti, Philippe J. ;
Burcelin, Remy .
EMBO MOLECULAR MEDICINE, 2011, 3 (09) :559-572
[2]   Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes (Publication with Expression of Concern. See JAN, 2023) [J].
Asemi, Zatollah ;
Zare, Zohreh ;
Shakeri, Hossein ;
Sabihi, Sima-sadat ;
Esmaillzadeh, Ahmad .
ANNALS OF NUTRITION AND METABOLISM, 2013, 63 (1-2) :1-9
[3]  
Astrup A, 2000, Obes Rev, V1, P57, DOI 10.1046/j.1467-789x.2000.00013.x
[4]   Type 1 diabetes [J].
Atkinson, Mark A. ;
Eisenbarth, George S. ;
Michels, Aaron W. .
LANCET, 2014, 383 (9911) :69-82
[5]  
Aw Wanping, 2015, Diseases, V3, P341, DOI 10.3390/diseases3040341
[6]   Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach [J].
Aw, Wanping ;
Fukuda, Shinji .
SEMINARS IN IMMUNOPATHOLOGY, 2015, 37 (01) :5-16
[7]   A Narrative Review of Diabetes Intervention Studies to Explore Diabetes Care Opportunities for Pharmacists [J].
Ayadurai, Shamala ;
Hattingh, H. Laetitia ;
Tee, Lisa B. G. ;
Said, Siti Norlina Md .
JOURNAL OF DIABETES RESEARCH, 2016, 2016
[8]   Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells [J].
Belcheva, Antoaneta ;
Irrazabal, Thergiory ;
Robertson, Susan J. ;
Streutker, Catherine ;
Maughan, Heather ;
Rubino, Stephen ;
Moriyama, Eduardo H. ;
Copeland, Julia K. ;
Kumar, Sachin ;
Green, Blerta ;
Geddes, Kaoru ;
Pezo, Rossanna C. ;
Navarre, William W. ;
Milosevic, Michael ;
Wilson, Brian C. ;
Girardin, Stephen E. ;
Wolever, Thomas M. S. ;
Edelmann, Winfried ;
Guttman, David S. ;
Philpott, Dana J. ;
Martin, Alberto .
CELL, 2014, 158 (02) :288-299
[9]   An estimation of the number of cells in the human body [J].
Bianconi, Eva ;
Piovesan, Allison ;
Facchin, Federica ;
Beraudi, Alina ;
Casadei, Raffaella ;
Frabetti, Flavia ;
Vitale, Lorenza ;
Pelleri, Maria Chiara ;
Tassani, Simone ;
Piva, Francesco ;
Perez-Amodio, Soledad ;
Strippoli, Pierluigi ;
Canaider, Silvia .
ANNALS OF HUMAN BIOLOGY, 2013, 40 (06) :463-471
[10]   Genetics, pathogenesis and clinical interventions in type 1 diabetes [J].
Bluestone, Jeffrey A. ;
Herold, Kevan ;
Eisenbarth, George .
NATURE, 2010, 464 (7293) :1293-1300