Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models

被引：54
作者：
Carlton, JMR
Hayton, M
Cravo, PVL
Walliker, D
机构：
[1] NIH, Natl Ctr Biotechnol Res, Natl Lib Med, Bethesda, MD 20892 USA
[2] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland
来源：
TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S1471-4922(01)01899-2
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria central. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.
引用
收藏
页码：236 / 242
页数：7
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