KRAS inhibitors, approved

被引：21

作者：

Rosell, Rafael ^{[1
,2
,3
]}

Aguilar, Andres ^{[2
]}

Pedraz, Carlos ^{[3
]}

Chaib, Imane ^{[3
]}

机构：

[1] Catalan Inst Oncol, Badalona, Spain

[2] Oncol Inst Dr Rosell, IOR, Barcelona, Spain

[3] Germans Trias & Pujol Res Inst IGTP, Badalona, Spain

来源：

NATURE CANCER | 2021年 / 2卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

KRAS(G12C);

D O I：

10.1038/s43018-021-00289-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rapid progression of KRAS(G12C) inhibitors from preclinical characterization to the clinic has radically changed the perception of the KRAS oncogene as an undruggable target. Here we discuss ongoing and future possibilities for developing therapies using these inhibitors in clinical settings.

引用

页码：1254 / 1256

页数：3

共 11 条

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