Phytochemical and pharmacological study of Sedum dendroideum leaf juice

被引：30

作者：

De Melo, GO

Malvar, DD

Vanderlinde, FA

Pires, PA

Côrtes, WS

Filho, PG

Muzitano, MF

Kaiser, CR

Costa, SS ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, BR-21941590 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Biol, Dept Ciencias Fisiol, BR-23850000 Seropedica, RJ, Brazil

[3] Univ Fed Rio de Janeiro, Inst Biol, Dept Bot, BR-850000 Seropedica, RJ, Brazil

[4] Univ Fed Rio de Janeiro, Inst Quim, BR-21941972 Rio De Janeiro, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 102卷 / 02期

关键词：

Sedum dendroideum; Crassulaceae; kaempferol glycosides; antinociceptive activity; anti-inflammatory activity;

D O I：

10.1016/j.jep.2005.06.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The fresh juice from leaves of Sedum dendroideum Moc & Sesse (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1-1 g/kg) of the lyophilized Sedum dendroideum juice (LJ) caused a significant dose-related reduction of acetic acid-induced writhing response (ID50 = 631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1 g/kg) in mice. In the formalin-induced nociception in mice, LJ (1 g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：217 / 220

页数：4

共 19 条

[1]

Camargo MEM, 2002, P W PHARMACOL SOC, V45, P129

[2]

CARLINI E A, 1970, Anais da Academia Brasileira de Ciencias, V42, P267

[3]

D'amour FE, 1941, J PHARMACOL EXP THER, V72, P74

[4] DISSOCIATION BETWEEN ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF ACETYLSALICYLIC-ACID AND INDOMETHACIN IN THE FORMALIN TEST [J].