Boosting Natural Killer Cell-Based Immunotherapy with Anticancer Drugs: a Perspective

被引：42

作者：

Cifaldi, Loredana ^{[1
]}

Locatelli, Franco ^{[1
,2
]}

Marasco, Emiliano ^{[3
]}

Moretta, Lorenzo ^{[4
]}

Pistoia, Vito ^{[4
]}

机构：

[1] Osped Pediat Bambino Gesu, IRCCS, Dept Pediat Haematol Oncol, Rome, Italy

[2] Univ Pavia, Dept Pediat Sci, Pavia, Italy

[3] Osped Pediat Bambino Gesu, IRCCS, Dept Rheumatol, Rome, Italy

[4] Osped Pediat Bambino Gesu, IRCCS, Immunol Res Area, Rome, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 12期

关键词：

HISTONE DEACETYLASE INHIBITOR; NKG2D LIGAND EXPRESSION; DNA-DAMAGE RESPONSE; I-RELATED CHAIN; HUMAN NK CELLS; HUMAN OSTEOSARCOMA CELLS; INNATE IMMUNE-RESPONSE; MULTIPLE-MYELOMA CELLS; VIRUS-INFECTED CELLS; LUNG-CANCER CELLS;

D O I：

10.1016/j.molmed.2017.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural killer (NK) cells efficiently recognize and kill tumor cells through several mechanisms including the expression of ligands for NK cell-activating receptors on target cells. Different clinical trials indicate that NK cell-based immunotherapy represents a promising antitumor treatment. However, tumors develop immune-evasion strategies, including downregulation of ligands for NK cell-activating receptors, that can negatively affect antitumor activity of NK cells, which either reside endogenously, or are adoptively transferred. Thus, restoration of the expression of NK cell-activating ligands on tumor cells represents a strategic therapeutic goal. As discussed here, various anticancer drugs can fulfill this task via different mechanisms. We envision that the combination of selected chemotherapeutic agents with NK cell adoptive transfer may represent a novel strategy for cancer immunotherapy.

引用

页码：1156 / 1175

页数：20

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