ZnO/Ag nanohybrid: synthesis, characterization, synergistic antibacterial activity and its mechanism

被引：177
作者：
Ghosh, Somnath [1 ]
Goudar, V. S. [1 ]
Padmalekha, K. G. [2 ]
Bhat, S. V. [2 ]
Indi, S. S. [3 ]
Vasan, H. N. [1 ]
机构：
[1] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India
[3] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India
来源：
RSC ADVANCES | 2012年 / 2卷 / 03期
关键词：
ESCHERICHIA-COLI; SILVER NANOPARTICLES; CONVERSION-EFFICIENCY; STAPHYLOCOCCUS-AUREUS; NEW-GENERATION; WATER; DISINFECTION; ADSORPTION; NANOCRYSTALLITES; NANOCOMPOSITES;
D O I：
10.1039/c1ra00815c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly homogeneous ZnO/Ag nanohybrid has been synthesized by a novel route, employing chitosan as mediator by purely electrostatic interaction. By employing various techniques such as powder XRD, UV-visible, IR spectroscopy and electron (SEM, TEM) microscopy, the formation of the nanohybrid has been established. The synergistic antibacterial effect of ZnO/Ag nanohybrid on Gram-positive and Gram-negative bacteria is found to be more effective, compared to the individual components (ZnO and Ag). Cytotoxicity experiments are carried out and the results are correlated to the solubility of the nanohybrid. A possible mechanism has been proposed for the antibacterial activity of ZnO/Ag nanohybrid, based on TEM studies on bacteria, carried out by employing the microtome technique and by EPR measurements on the hybrid.
引用
收藏
页码：930 / 940
页数：11
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