Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal

被引：5

作者：

Yang Cai-qin ^{[1
]}

Wang Jing ^{[1
]}

Zhang Zhen-wei ^{[2
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Peoples R China

[2] Capital Normal Univ, Beijing Key Lab Terahertz Spect & Imaging, Dept Phys, Beijing 100048, Peoples R China

来源：

SPECTROSCOPY AND SPECTRAL ANALYSIS | 2011年 / 31卷 / 09期

关键词：

Active pharmaceutical ingredient (API); IR; Raman; THz spectra; Co-crystal; SPECTROSCOPY; COCRYSTALS; RAMAN; DRUG;

D O I：

10.3964/j.issn.1000-0593(2011)09-2476-04

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient (API), which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates (pseudo-polymorphs). In our study, dipfluzine hydrochloride-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.

引用

页码：2476 / 2479

页数：4

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