The regulation of proteasome degradation by multi-ubiquitin chain binding proteins

被引：50

作者：

Miller, J ^{[1
]}

Gordon, C ^{[1
]}

机构：

[1] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

FEBS LETTERS | 2005年 / 579卷 / 15期

关键词：

proteasome; ubiquitin; UIM; UBA; UBL; UBX;

D O I：

10.1016/j.febslet.2005.03.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 26S proteasome is a large multi-protein complex that functions to degrade proteins tagged with multi-ubiquitin chains. There are several mechanisms employed by the cell to ensure the efficient delivery of multi-ubiquitinated substrate proteins to the 26S proteasome. This is not only important to ensure the degradation of damaged and misfolded proteins, but also the regulated turnover of critical cell regulators. This discussion will concentrate on what is known about the recognition and delivery of ubiquitinated substrate proteins to the 26S proteasome. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3224 / 3230

页数：7