Fine Needle Aspiration Cytology of Solid Neuroendocrine Carcinoma of the Breast: A Case Report

被引:11
作者
Kawanishi, Namiki [2 ]
Norimatsu, Yoshiaki [3 ]
Funakoshi, Mahito [4 ]
Kamei, Toshiaki [5 ]
Sonobe, Hiroshi [6 ]
Kawano, Ryo [7 ]
Kobayashi, Tadao K. [1 ]
机构
[1] Imperial Gift Fdn Inc, Saiseikai Shiga Hosp, Dept Cytopathol, Shiga 5203046, Japan
[2] Mihara Med Assoc Hosp, Dept Clin Lab, Hiroshima, Japan
[3] Ehime Prefectural Univ Hlth Sci, Dept Med Technol, Ehime, Japan
[4] JA Hiroshima Gen Hosp, Dept Breast Oncol, Hiroshima, Japan
[5] Yamaguchi Grand Med Ctr, Dept Pathol, Yamaguchi, Japan
[6] Chugoku Cent Hosp, Dept Lab Med, Hiroshima, Japan
[7] Kawano Med Clin, Dept Surg, Hiroshima, Japan
关键词
breast cancer; neuroendocrine tumor; cytology; plasmacytoid cells; immunocytochemistry;
D O I
10.1002/dc.21494
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
We report a case of neuroendcrine (NE) carcinoma in the right breast of a 67-year-old female, ultrasonography revealed a lesion composed of irregular hypoechoic masses and mammography showed asymmetric breast tissue. Histopathologic examination of the surgical sample showed a solid to nested proliferation of plasmacytoid cells that showed immunocytochemical positivity for chromogranin A, synaptophysin, CD56, and estrogen receptor. Our case was diagnosed as solid NE carcinoma. Though the findings of fine needle aspiration cytology reflected the histological features, we were not able to cytopathologic grounds only to predict the NE nature of this tumor. We performed immunocytochemistry using Chromogranin A, Synaptophysin, and CD56 on our cytologic smear retrospectively with positive results for all of the markers. When the cytopathologic examination of a given breast neoplasm is suggestive of NE differentiation, immunocytochemical staining for NE markers is generally useful for a correct preoperative diagnosis. An acurate preoperative diagnosis of NE carcinoma on FNAC can be achieved based on its distinctive cytomorphologic and immunocytochemical features. Diagn. Cytopathol. 2011; 39: 527-530. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:527 / 530
页数:4
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