Negishi-type coupling of bromoarenes with dimethylzinc

被引：52

作者：

Herbert, JM ^{[1
]}

机构：

[1] Sanofi Synthelabo, Isotope Chem & Metabolite Synth Dept, Alnwick NE66 2JH, Northd, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 04期

关键词：

arene alkylation; palladium; Negishi coupling;

D O I：

10.1016/j.tetlet.2003.11.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of bromoarenes with dimethylzinc in the presence of a palladium catalyst provides a high-yielding route to methylarenes. The process accommodates a wide range of aromatic substituents and, in the majority of cases, is free of side reactions. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：817 / 819

页数：3

共 5 条

[1] Convenient synthesis of aromatic thiols from phenols [J].

Arnould, JC ;

Didelot, M ;

Cadilhac, C ;

Pasquet, MJ .

TETRAHEDRON LETTERS, 1996, 37 (26) :4523-4524

[2] TRANSITION-METAL CATALYZED-REACTIONS OF ORGANOZINC REAGENTS [J].

ERDIK, E .

TETRAHEDRON, 1992, 48 (44) :9577-9648

[3] Practical methylation of aryl halides by Suzuki-Miyaura coupling [J].

Gray, M ;

Andrews, IP ;

Hook, DF ;

Kitteringham, J ;

Voyle, M .

TETRAHEDRON LETTERS, 2000, 41 (32) :6237-6240

[4] PREPARATION AND REACTIONS OF POLYFUNCTIONAL ORGANOZINC REAGENTS IN ORGANIC-SYNTHESIS [J].

KNOCHEL, P ;

SINGER, RD .

CHEMICAL REVIEWS, 1993, 93 (06) :2117-2188

[5] SELECTIVE MONO-ALKYLATION AND ARYLATION OF AROMATIC DIHALIDES BY PALLADIUM-CATALYZED CROSS-COUPLING WITH THE GRIGNARD AND ORGANOZINC REAGENTS [J].

MINATO, A ;

TAMAO, K ;

HAYASHI, T ;

SUZUKI, K ;

KUMADA, M .

TETRAHEDRON LETTERS, 1980, 21 (09) :845-848

← 1 →