The lipid rafts in cancer stem cell: a target to eradicate cancer

被引：22
|
作者：
Zhang, Shuo [1 ]
Zhu, Neng [2 ]
Li, Hong Fang [1 ]
Gu, Jia [1 ]
Zhang, Chan Juan [1 ]
Liao, Duan Fang [1 ]
Qin, Li [1 ,3 ,4 ]
机构：
[1] Hunan Univ Chinese Med, Sch Pharm, Lab Stem Cell Regulat Chinese Med & Its Applicat, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Dept Urol, Hosp 1, Changsha, Peoples R China
[3] Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha, Peoples R China
[4] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery Tr, Changsha, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2022年 / 13卷 / 01期
关键词：
Lipid raft; Cancer; Cancer stem cell; Self-renewal; Drug resistance; Epithelial-mesenchymal transition; Cancer stem cell niche; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN HEMATOPOIETIC STEM; TUMOR-GROWTH; SELF-RENEWAL; ELEVATED EXPRESSION; SIGNALING PATHWAYS; INDUCED APOPTOSIS; GAMMA-SECRETASE; DRUG-RESISTANCE; SURFACE-MARKERS;
D O I：
10.1186/s13287-022-03111-8
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in the plasma membrane that mediate various intracellular signaling. The occurrence and progression of cancer are closely related to lipid rafts. Emerging evidence indicates that lipid raft levels are significantly enriched in CSCs compared to cancer cells and that most CSC markers such as CD24, CD44, and CD133 are located in lipid rafts. Furthermore, lipid rafts play an essential role in CSCs, specifically in CSC self-renewal, epithelial-mesenchymal transition, drug resistance, and CSC niche. Therefore, lipid rafts are critical regulatory platforms for CSCs and promising therapeutic targets for cancer therapy.
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页数：15
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