Medication Adherence in Patients with Bipolar Disorder: A Comprehensive Review

被引：64
作者：
Levin, Jennifer B. [1 ,2 ]
Krivenko, Anna [1 ,4 ]
Howland, Molly [1 ]
Schlachet, Rebecca [1 ]
Sajatovic, Martha [1 ,2 ,3 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Psychiat, Univ Hosp Case Med Ctr, 10524 Euclid Ave, Cleveland, OH 44106 USA
[2] Univ Hosp Case Med Ctr, Neurol & Behav Outcomes Ctr, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Univ Hosp Case Med Ctr, Dept Neurol, 10524 Euclid Ave, Cleveland, OH 44106 USA
[4] Cleveland State Univ, Dept Psychol, 2300 Chester Ave, Cleveland, OH 44115 USA
来源：
CNS DRUGS | 2016年 / 30卷 / 09期
关键词：
RANDOMIZED CONTROLLED-TRIAL; SEVERE MENTAL-ILLNESS; ACTING INJECTABLE ANTIPSYCHOTICS; TERM LITHIUM TREATMENT; OF-THE-LITERATURE; I DISORDER; TREATMENT NONADHERENCE; MAINTENANCE TREATMENT; HEALTH-CARE; PHARMACOLOGICAL ADHERENCE;
D O I：
10.1007/s40263-016-0368-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Poor medication adherence is a pervasive problem that causes disability and suffering as well as extensive financial costs among individuals with bipolar disorder (BD). Barriers to adherence are numerous and cross multiple levels, including factors related to bipolar pathology and those unique to an individual's circumstances. External factors, including treatment setting, healthcare system, and broader health policies, can also affect medication adherence in people with BD. Fortunately, advances in research have suggested avenues for improving adherence. A comprehensive review of adherence-enhancement interventions for the years 2005-2015 is included. Specific bipolar adherence-enhancement approaches that target knowledge gaps, cognitive patterns, specific barriers, and motivation may be helpful, as may approaches that capitalize on technology or novel drug-delivery systems. However, much work remains to optimally facilitate long-term medication adherence in people with BD. For adherence-enhancement approaches to be widely adapted, they need to be easily accessible, affordable, and practical.
引用
收藏
页码：819 / 835
页数：17
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