Risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy: a retrospective Chinese population study

被引:34
作者
Wang, Ying-hao [1 ]
Bhandari, Adheesh [1 ]
Yang, Fan [1 ]
Zhang, Wei [1 ]
Xue, Li-jun [1 ]
Liu, Hai-guang [1 ]
Zhang, Xiao-hua [1 ]
Chen, Cheng-ze [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Wenzhou 325000, Zhejiang, Peoples R China
来源
CANCER MANAGEMENT AND RESEARCH | 2017年 / 9卷
基金
中国国家自然科学基金;
关键词
hypocalcemia; hypoparathyroidism; thyroidectomy; risk factor; POSTOPERATIVE PARATHYROID-HORMONE; LYMPH-NODE; VITAMIN-D; PERMANENT HYPOPARATHYROIDISM; CARBON NANOPARTICLES; COMPLICATIONS; SURGERY; CANCER; AUTOTRANSPLANTATION; DISSECTION;
D O I
10.2147/CMAR.S148090
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hypocalcemia is one of the most common postoperative complications following thyroid surgery in clinical practice. The occurrence of hypocalcemia is mainly attributed to hypoparathyroidism when parathyroid glands are devascularized, injured, or dissected during the surgery. The aim of this study was to analyze the risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy. Patients and methods: A total of 278 patients who underwent thyroid surgery were analyzed retrospectively. Univariate analysis and multivariable logistic regression were performed to discover the risk factors for hypocalcemia and hypoparathyroidism. Results: Postoperative hypocalcemia occurred in 76 (27.3%) patients and hypoparathyroidism occurred in 42 (15.1%) patients. Seven factors were significantly related to the presence of postoperative hypocalcemia, namely, age (P=0.049), gender (P=0.015), lateral lymph node dissection (P=0.017), operation type (P<0.001), preoperative parathyroid hormone (PTH) level (P=0.035), operation time (P=0.001), and applying carbon nanoparticles (CNs; P=0.007). Our result revealed that gender (P=0.014), lateral lymph node dissection (P=0.038), operation type (P<0.001), operative time (P<0.001), and applying CNs (P=0.001) had a significant correlation with postoperative hypoparathyroidism. Conclusion: These findings were crucial for guiding surgeons to prevent the occurrence of hypocalcemia and hypoparathyroidism.
引用
收藏
页码:627 / 635
页数:9
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