Rh(iii)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

被引：20

作者：

Pan, Changduo ^{[1
]}

Huang, Gao ^{[2
]}

Shan, Yujia ^{[2
]}

Li, Yiting ^{[2
]}

Yu, Jin-Tao ^{[2
]}

机构：

[1] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China

[2] Changzhou Univ, Jiangsu Key Lab Adv Catalyt Mat & Technol, Sch Petrochem Engn, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 16期

基金：

中国国家自然科学基金;

关键词：

H ACTIVATION; OXIDATIVE ALKYLATION; HECK REACTION; FUNCTIONALIZATION; ALLYLATION; ARYLATION; OLEFINATION; C7-FUNCTIONALIZATION; ALKENYLATION; INDOLINES;

D O I：

10.1039/d0ob00396d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(iii)-catalyzed and weak coordination carbonyl guided direct C4 alkylation of indoles with allylic alcohols was developed with excellent regioselectivity. This reaction was conducted under mild conditions, leading to a variety of beta-indolyl ketones with good functional group tolerance in moderate to good yields.

引用

页码：3038 / 3042

页数：5

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