NEW ROUTE TO NOVEL POLYSUBSTITUTED QUINOLINES STARTING WITH EUGENOL, THE MAIN CONSTITUENT OF OCIMUM SANCTUM L. OIL

被引：9

作者：

Nguyen Huu Dinh ^{[1
]}

LeVan Co ^{[1
]}

Nguyen Manh Tuan ^{[1
]}

Le Thi Hong Hai ^{[1
]}

Van Meervelt, Luc ^{[2
]}

机构：

[1] Hanoi Natl Univ Educ, Dept Chem, Hanoi, Vietnam

[2] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium

来源：

HETEROCYCLES | 2012年 / 85卷 / 03期

关键词：

Quinoline; Cyclization; Eugenol; Eugenoxyacetic Acid; Ocimum sanctum L. Oil; IMINES;

D O I：

10.3987/COM-11-12416

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple method has been reported for the synthesis of (6-hydroxy-3-sulfoquinolin-7-yloxy)acetic acid (Q1) starting with eugenol, the main constituent of Ocimum sanctum L. oil. The reaction pathway from a quinone-aci compound to the quinoline compound Q1 was proposed on the basis of H-1 NMR method. Q1 was used as a key compound for further transformation to 9 novel polysubstituted quinolines. The structure of the synthesized compounds was characterized by spectroscopic methods.

引用

页码：627 / 637

页数：11

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