Human Papillomavirus Is Associated with Breast Cancer in the North Part of Iran

被引：49

作者：

Sigaroodi, Afsaneh ^{[2
]}

Nadji, Seyed Alireza ^{[1
]}

Naghshvar, Farshad ^{[3
]}

Nategh, Rakhshandeh ^{[2
]}

Emami, Habib ^{[4
]}

Velayati, Ali Akbar ^{[5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Virol Res Ctr, Tehran 1956944413, Iran

[2] Islamic Azad Univ, Sci & Res Ctr, Dept Biol, Tehran 1477893855, Iran

[3] Mazandaran Univ Med Sci, Imam Khomeini Hosp, Dept Pathol, Sari 4816633131, Iran

[4] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Tobacco Prevent & Control Res Ctr, Tehran 1956944413, Iran

[5] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Chron Resp Dis Res Ctr, Tehran 1956944413, Iran

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

关键词：

CERVICAL-CANCER; HPV INFECTION; LUNG-CANCER; NO EVIDENCE; DNA; SEQUENCES; LESIONS; STATISTICS; CARCINOMA; ETIOLOGY;

D O I：

10.1100/2012/837191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have analyzed the possible relevance of HPV infection for breast cancer risk among Iranian women from north part of Iran. Among women with breast cancer, 25.9% had positive test results for HPV DNA in breast tumor samples in contrast to 2.4% of women with noncancer status (P = 0.002). The infection of HPV has increased the risk of breast cancer (OR 14.247; 95% CI 1.558-130.284, P = 0.019). The high-risk HPV genotypes (types 16 and 18) in samples of breast cancer patients were the predominant types (53.34%). Other genotypes detected in breast cancer were HPV-6, HPV-11, HPV-15, HPV-23, and HPV-124, and one isolate could not be genotyped compared to HPV reference sequences. While the sole detected HPV in control specimens was HPV-124. Our study reveals that HPV infection and age are the risk factors in breast cancer development in the north part of Iran.

引用

页码：1 / 8

页数：8

共 40 条

[11] Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast
de Villiers, EM
Sandstrom, RE
zur Hausen, H
Buck, CE
[J]. BREAST CANCER RESEARCH, 2005, 7 (01) : R1 - R11
[12] deVilliers EM, 1997, INT J CANCER, V73, P356, DOI 10.1002/(SICI)1097-0215(19971104)73:3<356::AID-IJC9>3.3.CO
[13] 2-S
[14] HUMAN PAPILLOMAVIRUS IN BREAST-CANCER
DILONARDO, A
VENUTI, A
MARCANTE, ML
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1992, 21 (02) : 95 - 100
[15] Mammary epithelial cell transformation: insights from cell culture and mouse models
Dimri, G
Band, H
Band, V
[J]. BREAST CANCER RESEARCH, 2005, 7 (04): : 171 - 179
[16] A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin
Forslund, O
Antonsson, A
Nordin, P
Stenquist, B
Hansson, BG
[J]. JOURNAL OF GENERAL VIROLOGY, 1999, 80 : 2437 - 2443
[17] Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction
Gopalkrishna, V
Singh, UR
Sodhani, P
Sharma, JK
Hedau, ST
Mandal, AK
Das, BC
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1996, 39 (02) : 197 - 202
[18] Gumus M, 2006, J EXP CLIN CANC RES, V25, P515
[19] Human papilloma virus is associated with breast cancer
Heng, B.
Glenn, W. K.
Ye, Y.
Tran, B.
Delprado, W.
Lutze-Mann, L.
Whitaker, N. J.
Lawson, J. S.
[J]. BRITISH JOURNAL OF CANCER, 2009, 101 (08) : 1345 - 1350
[20] Human papillomavirus 16 in breast cancer of women treated for high grade cervical intraepithelial neoplasia (CIN III).
Hennig, EM
Suo, ZH
Thoresen, S
Holm, R
Kvinnsland, S
Nesland, JM
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1999, 53 (02) : 121 - 135

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