Human Papillomavirus Is Associated with Breast Cancer in the North Part of Iran

被引：49

作者：

Sigaroodi, Afsaneh ^{[2
]}

Nadji, Seyed Alireza ^{[1
]}

Naghshvar, Farshad ^{[3
]}

Nategh, Rakhshandeh ^{[2
]}

Emami, Habib ^{[4
]}

Velayati, Ali Akbar ^{[5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Virol Res Ctr, Tehran 1956944413, Iran

[2] Islamic Azad Univ, Sci & Res Ctr, Dept Biol, Tehran 1477893855, Iran

[3] Mazandaran Univ Med Sci, Imam Khomeini Hosp, Dept Pathol, Sari 4816633131, Iran

[4] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Tobacco Prevent & Control Res Ctr, Tehran 1956944413, Iran

[5] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, NRITLD, Chron Resp Dis Res Ctr, Tehran 1956944413, Iran

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

关键词：

CERVICAL-CANCER; HPV INFECTION; LUNG-CANCER; NO EVIDENCE; DNA; SEQUENCES; LESIONS; STATISTICS; CARCINOMA; ETIOLOGY;

D O I：

10.1100/2012/837191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have analyzed the possible relevance of HPV infection for breast cancer risk among Iranian women from north part of Iran. Among women with breast cancer, 25.9% had positive test results for HPV DNA in breast tumor samples in contrast to 2.4% of women with noncancer status (P = 0.002). The infection of HPV has increased the risk of breast cancer (OR 14.247; 95% CI 1.558-130.284, P = 0.019). The high-risk HPV genotypes (types 16 and 18) in samples of breast cancer patients were the predominant types (53.34%). Other genotypes detected in breast cancer were HPV-6, HPV-11, HPV-15, HPV-23, and HPV-124, and one isolate could not be genotyped compared to HPV reference sequences. While the sole detected HPV in control specimens was HPV-124. Our study reveals that HPV infection and age are the risk factors in breast cancer development in the north part of Iran.

引用

页码：1 / 8

页数：8

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