Testing the involvement of baroreflex during general anesthesia through Granger causality approach

被引：12

作者：

Bassani, Tito ^{[1
,2
]}

Magagnin, Valentina

Guzzetti, Stefano ^{[3
]}

Baselli, Giuseppe ^{[2
]}

Citerio, Giuseppe ^{[4
]}

Porta, Alberto ^{[1
]}

机构：

[1] Univ Milan, Dept Technol Hlth, Galeazzi Orthopaed Inst, Milan, Italy

[2] Polytech Univ Milan, Dept Bioengn, Milan, Italy

[3] L Sacco Hosp Vialba, Dept Emergency, Milan, Italy

[4] San Gerardo Hosp, Neuroanaesthesia & Neurointens Care Unit, Dept Perioperat Med & Intens Care, Monza, Italy

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2012年 / 42卷 / 03期

关键词：

Granger causality; Baroreflex; General anesthesia; Autonomic nervous system; Cardiovascular control; HEART-RATE; ARTERIAL-PRESSURE; SPECTRUM ANALYSIS; TIME-SERIES; VARIABILITY; HUMANS; SENSITIVITY; PROPOFOL;

D O I：

10.1016/j.compbiomed.2011.03.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Baroreflex sensitivity (BRS) is commonly assessed from spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) during general anesthesia. Unfortunately, general anesthesia depresses autonomic function and, consequently, spontaneous SAP variations could not be capable to drive HP changes, thus preventing the use of spontaneous variability to infer BRS. We applied two Granger causality approaches (F-test and Wald test) during two anesthesiological strategies (i.e. sevoflurane plus remifentanil or propofol plus remifentanil). We found a significant Granger-causality from SAP to HP independently of the anesthesiological strategy; thus suggesting that techniques estimating BRS from spontaneous variability can be utilized during general anesthesia. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：306 / 312

页数：7

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