Role of tyrosine kinase inhibitors in the management of high-grade gliomas

被引：0

作者：

Ahluwalia, Manmeet S. ^{[1
]}

Patel, Mital ^{[2
]}

Peereboom, David M. ^{[1
]}

机构：

[1] Cleveland Clin, Rose Ella Burkhardt Brain Tumor & Neurooncol Ctr, Neurol Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin, Dept Hosp Med, Cleveland, OH 44195 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2011年 / 11卷 / 11期

关键词：

brain tumors; chemotherapy; high-grade gliomas; resistance; tyrosine kinase; tyrosine kinase inhibitors; GROWTH-FACTOR RECEPTOR; PHASE-II TRIAL; RECURRENT MALIGNANT GLIOMAS; DIAGNOSED GLIOBLASTOMA-MULTIFORME; RESISTANCE PROTEIN ABCG2; BRAIN-TUMOR CONSORTIUM; P-GLYCOPROTEIN ABCB1; IMATINIB MESYLATE; RADIATION-THERAPY; PLUS HYDROXYUREA;

D O I：

10.1586/ERA.11.166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent years have witnessed an explosion of promising therapies for cancer patients. New insights into the biology of malignancies have led to the development of targeted agents with the potential to improve survival and quality of life. One of the most important classes of these compounds are tyrosine kinase inhibitors. These agents are beginning to offer a clinically relevant benefit to patients with tumors that until recently have been refractory to medical therapies. High-grade gliomas represent one class of medically refractory solid tumors. This article summarizes the state of the art of tyrosine kinase inhibitors in the management of patients with high-grade gliomas.

引用

页码：1739 / 1748

页数：10

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