Transgenic plants as protein factories

被引:122
作者
Giddings, G [1 ]
机构
[1] Univ Wales, Inst Biol Sci, Aberystwyth SY23 3DD, Dyfed, Wales
关键词
D O I
10.1016/S0958-1669(00)00244-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Transgenic plants are showing considerable potential for the economic production of proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals produced from transgenic plants are encouraging, with plant glycans showing reassuringly poor immunogenicity. Our increasing understanding of protein targeting and accumulation should further improve the potential of this new technology.
引用
收藏
页码:450 / 454
页数:5
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共 57 条
  • [1] Gene expression patterns and cancer
    Szallasi, Z
    [J]. NATURE BIOTECHNOLOGY, 1998, 16 (13) : 1292 - 1293
  • [2] Effect of processing on the recovery of recombinant β-glucuronidase (rGUS) from transgenic canola
    Bai, Y
    Nikolov, ZL
    [J]. BIOTECHNOLOGY PROGRESS, 2001, 17 (01) : 168 - 174
  • [3] Cowpea mosaic virus as a vaccine carrier of heterologous antigens
    Brennan, FR
    Jones, TD
    Hamilton, WDO
    [J]. MOLECULAR BIOTECHNOLOGY, 2001, 17 (01) : 15 - 26
  • [4] N-glycosylation of a mouse IgG expressed in transgenic tobacco plants
    Cabanes-Macheteau, M
    Fitchette-Lainé, AC
    Loutelier-Bourhis, C
    Lange, C
    Vine, ND
    Ma, JKC
    Lerouge, P
    Faye, L
    [J]. GLYCOBIOLOGY, 1999, 9 (04) : 365 - 372
  • [5] A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice
    Chargelegue, D
    Vine, ND
    van Dolleweerd, CJ
    Drake, PMW
    Ma, JKC
    [J]. TRANSGENIC RESEARCH, 2000, 9 (03) : 187 - 194
  • [6] Expression of full-length bioactive antimicrobial human lactoferrin in potato plants
    Chong, DKX
    Langridge, WHR
    [J]. TRANSGENIC RESEARCH, 2000, 9 (01) : 71 - 78
  • [7] Expression of the human milk protein beta-casein in transgenic potato plants
    Chong, DKX
    Roberts, W
    Arakawa, T
    Illes, K
    Bagi, G
    Slattery, CW
    Langridge, WHR
    [J]. TRANSGENIC RESEARCH, 1997, 6 (04) : 289 - 296
  • [8] Bioproduction of human enzymes in transgenic tobacco
    Cramer, CL
    Weissenborn, DL
    Oishi, KK
    Grabau, EA
    Bennett, S
    Ponce, E
    Grabowski, GA
    Radin, DN
    [J]. ENGINEERING PLANTS FOR COMMERCIAL PRODUCTS AND APPLICATIONS, 1996, 792 : 62 - 71
  • [9] ASSEMBLY OF AN ANTIBODY AND ITS DERIVED ANTIBODY FRAGMENT IN NICOTIANA AND ARABIDOPSIS
    DENEVE, M
    DELOOSE, M
    JACOBS, A
    VANHOUDT, H
    KALUZA, B
    WEIDLE, U
    VANMONTAGU, M
    DEPICKER, A
    [J]. TRANSGENIC RESEARCH, 1993, 2 (04) : 227 - 237
  • [10] Foreign protein production in plant tissue cultures
    Doran, PM
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (02) : 199 - 204