Simplifying native chemical ligation with an N-acylsulfonamide linker

被引：17

作者：

Burlina, Fabienne ^{[2
]}

Morris, Caroline ^{[3
]}

Behrendt, Raymond ^{[4
]}

White, Peter ^{[1
]}

Offer, John ^{[3
]}

机构：

[1] Merck Chem, Beeston NG9 2JR, Notts, England

[2] UPMC Univ Paris 06, CNRS, ENS, Lab Biomol,UMR 7203, F-75005 Paris, France

[3] MRC Natl Inst Med Res, Div Phys Biochem, London NW7 1AA, England

[4] Merck & Cie, CH-8200 Schaffhausen, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 20期

关键词：

SOLID-PHASE SYNTHESIS; PANCREATIC TRYPSIN-INHIBITOR; TGF-BETA RECEPTOR; PEPTIDE-SYNTHESIS; THIOESTERS; SEMISYNTHESIS; ACTIVATION; CHEMISTRY;

D O I：

10.1039/c2cc15911b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.

引用

页码：2579 / 2581

页数：3

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