Lowering serum uric acid to prevent acute kidney injury

被引：17

作者：

Ejaz, A. Ahsan ^{[1
]}

Dass, Bhagwan ^{[1
]}

Kambhampati, Ganesh ^{[1
]}

Ejaz, Noel I. ^{[2
]}

Maroz, Natallia ^{[1
]}

Dhatt, Gurjit S. ^{[1
]}

Arif, Amir A. ^{[1
]}

Faldu, Chirag ^{[1
]}

Lanaspa, Miguel A. ^{[3
]}

Shah, Gaurav ^{[1
]}

Johnson, Richard J. ^{[3
]}

机构：

[1] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA

[2] Coll Univ Chicago, Chicago, IL USA

[3] Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Denver, CO USA

来源：

MEDICAL HYPOTHESES | 2012年 / 78卷 / 06期

关键词：

CARDIAC-SURGERY; GLOMERULAR HYPERTENSION; HYPERURICEMIA; COMPLICATION; MECHANISMS; DYNAMICS; CHILDREN; DISEASE; CELLS; RISK;

D O I：

10.1016/j.mehy.2012.03.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epidemiological, experimental and clinical studies support a role for uric acid in acute kidney injury (AKI). We discuss how the conventional role of uric acid in AKI has now evolved from intratubular crystal deposition to pro-inflammatory, anti-angiogenic and immunological function. Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：796 / 799

页数：4

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